Endocrine Abstracts

The misfolded proteins with abnormal polyglutamine (polyQ) expansion cause neurodegenerative disorders including Huntington’s disease (HD). Recently, Vaccinia-related kinase 2 (VRK2) were found to accumulate polyQ aggregates by controlling TCP-1 ring complex (TRiC)/Chaperonin-containing TCP-1 (CCT), which has an essential role in preventing against the aggregation and cytotoxicity of polyQ proteins. Interestingly, VRK2 expression is known to be much higher in actively pro...